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Horizon Therapeutics Public Limited Company

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Your Vote Counts! HORIZON THERAPEUTICS PLC 2022 Annual General Meeting Vote by April 27, 2022 11:59 PM ET HORIZON THERAPEUTICS PLC 70 ST. STEPHEN’S GREEN DUBLIN 2, D02 E2X4, IRELAND D68675-P66966 You invested in HORIZON THERAPEUTICS PLC and it’s time to vote! You have the right to vote on proposals being presented at the Annual General Meeting. This is an important notice regarding the availability of proxy material for the shareholder meeting to be held on April 28, 2022. Get informed before you vote View the Proxy Statement and the 2021 Annual Report to Shareholders online OR you can receive a free paper or email copy of the material(s) by requesting prior to April 14, 2022. If you would like to request a copy of the material(s) for this and/or future shareholder meetings, you may (1) visit, (2) call 1-800-579-1639 or (3) send an email to If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy. For complete information and to vote, visit Control # Smartphone users Point your camera here and vote without entering a control number Vote in Person at the Meeting* April 28, 2022 3:00 p.m. (local time) 70 St. Stephen’s Green Dublin 2, D02 E2X4, Ireland *Please check the meeting materials for any special requirements for meeting attendance. At the meeting, you will need to request a ballot to vote these shares. V1.1


Vote at THIS IS NOT A VOTABLE BALLOT This is an overview of the proposals being presented at the upcoming shareholder meeting. Please follow the instructions on the reverse side to vote these important matters. Voting Items Board Recommends 1. Election of Class II Director Nominees: 1a. Michael Grey For 1b. Jeff Himawan, Ph.D. For 1c. Susan Mahony, Ph.D. For 2. Approval of the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2022 and authorization of the Audit Committee to determine the auditors’ For remuneration. 3. Approval, on an advisory basis, of the compensation of our named executive officers, as disclosed in the Proxy Statement. For 4. Authorization for us and/or any of our subsidiaries to make market purchases or overseas market purchases of our For ordinary shares. 5. Approval of the Amended and Restated 2020 Equity Incentive Plan. For Prefer to receive an email instead? While voting on, be sure to click “Sign up for E-delivery”. D68676-P66966